Does HIV disease continues despite antiviral responses and antiretroviral therapy?
Combination antiretroviral therapy to treat human immunodeficiency virus (HIV)this disease has proven successful for those who can access and afford it – yet HIV disease persists indefinitely in a reservoir of cells, despite efficient and despite host antiviral immune responses. An HIV cure is accordinglythe next aspirational goal and challenge, though approaches different in their objectives with ‘functional cures’ aiming for durable viral control in the absence of ART, and ‘sterilizing cures’ aiming for the more difficult to realize objective of finalize viral eradication. Viral persistence through anatomical sequestration virus Anatomical sequestration of reservoir-harboring cells poses additional challenges to curative interfrence strategies, by limiting access to, and function of, immune effectors. incresingly, a new study from the “Last Gift” cohort involving rapid autopsy of PLWH found persistent HIV reservoirs crosswise 28 tissues, with multiple sites acting as ‘hu